An endometrial biopsy is a simple, in-office procedure that involves inserting a thin tube through the cervix and into the uterus to collect a tissue sample from the lining of the uterus, also known as the endometrium. The procedure typically takes less than 15 minutes.

The most common side effect after a biopsy is cramping. The cramping can be mild to moderate at times. It is rare for cramping pain to become severe. Many patients also report bleeding after the biopsy procedure. Spotting or light bleeding is normal, but you should contact your physician if it becomes heavy, or you are not feeling well.